Bisphosphonates-related osteonecrosis of the jaw in Korea: a preliminary report
이정근, 김경욱, 최진영, 문성용, 김수관, 김철환, 김현민, 권용대, 김용덕, 이동근, 민승기, 박인숙, 박영욱, 국민석, 박홍주, 백진아, 박준우, 권태건,
소속 상세정보
이정근 ( Lee Jeong-Keun ) - Ajou University Board of Bone Bank
김경욱 ( Kim Kyung-Wook ) - Dankook University
최진영 ( Choi Jin-Young ) - Seoul National University
문성용 ( Moon Seong-Yong ) - Chosun University
김수관 ( Kim Su-Gwan ) - Chosun University
김철환 ( Kim Chul-Hwan ) - Dankook University
김현민 ( Kim Hyeon-Min ) - Gachon University Gil Medical Center
권용대 ( Kwon Yong-Dae ) - Kyung Hee University
김용덕 ( Kim Yong-Deok ) - Pusan National University
이동근 ( Lee Dong-Keun ) - Daejeon Sun Hospital
민승기 ( Min Seung-Ki ) - Wonkwang University
박인숙 ( Park In-Sook ) - Catholic University of Daegu
박영욱 ( Park Young-Wook ) - Gangneung-Wonju National University
국민석 ( Kook Min-Suk ) - Chonam National University
박홍주 ( Park Hong-Ju ) - Chonam National University
백진아 ( Baek Jin-A ) - Chonbuk National University
박준우 ( Park Jun-Woo ) - Hallym University Kangdong Sacred Heart Hospital
권태건 ( Kwon Tae-Geon ) - Kyungpook National University
KMID : 0355620130390010009
Abstract
Objectives: Bisphosphonates (BP) are widely used in medicine for inhibiting bone resorption; however bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a major side effect of BP. To date, there have been no specific reports on the incidence of BRONJ among Koreans. This study investigated the preliminary results from a nationwide survey of BRONJ in the Departments of Oral and Maxillofacial Surgery (OMFS) at individual training hospitals.
Materials and Methods: A total of 15 OMFS departments (10 from dental schools, 4 from medical schools, and 1 from a dental hospital) participated in a multi-centric survey. This study assessed every BRONJ case diagnosed between January 2010 and December 2010. The patient age and BP type were evaluated.
Results: A total of 254 BRONJ cases were collected. The majority of BRONJ cases were associated with oral BP therapy, while 21.8% of the cases were associated with intravenous administration. Alendronate was the drug most frequently related to BRONJ (59.2% of cases), followed by risedronate (14.3%) and zolendronate (17.0%). The average age of BRONJ patients was 70.0±10.1 years, with a range of 38-88 years of age. With the number of BP patients in Korea reported to be around 600,000 in 2008, the estimated incidence of BRONJ is at least 0.04% or 1 per 2,300 BP patients.
Conclusion: The results suggest that the estimated incidence of BRONJ in Korea is higher than the incidence of other countries. Future prospective studies should be carried out to investigate the exact epidemiological characteristics of BRONJ in Korea.
키워드
Bisphosphonate; Osteonecrosis; Jaw; Data collection
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